Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
drd5_human | 23 | N-term | Q => Ter | stop gained | 2.802e-05 | 1 | 35686 | 0 | None | None | ||
drd5_human | 62 | 1.54x54 | TM1 | C => Ter | stop gained | 0.0009874 | 111 | 112420 | 0 | None | None | |
drd5_human | 113 | 3.25x25 | TM3 | C => Ter | stop gained | 8.247e-06 | 1 | 121250 | 0 | None | None | |
drd5_human | 116 | 3.28x28 | TM3 | W => Ter | stop gained | 5.773e-05 | 7 | 121252 | 0 | None | None | LB (polar (hydrogen bond)) |
drd5_human | 165 | 4.50x50 | TM4 | W => Ter | stop gained | 8.288e-06 | 1 | 120660 | 0 | None | None | |
drd5_human | 197 | ECL2 | L => TrpfsTer16 | frameshift | 8.34e-06 | 1 | 119910 | 0 | None | None | ||
drd5_human | 204 | ECL2 | E => Ter | stop gained | 4.16e-05 | 5 | 120180 | 0 | None | None | ||
drd5_human | 223 | 5.36x37 | TM5 | R => Ter | stop gained | 1.652e-05 | 2 | 121076 | 0 | None | None | |
drd5_human | 252 | 5.65x65 | TM5 | A => ProfsTer49 | frameshift | 8.323e-06 | 1 | 120152 | 0 | None | None | GP (contact) |
drd5_human | 255 | 5.68x68 | TM5 | Q => Ter | stop gained | 8.348e-06 | 1 | 119796 | 0 | None | None | GP (contact) |
drd5_human | 278 | ICL3 | C => Ter | stop gained | 3.496e-05 | 4 | 114422 | 0 | None | None | ||
drd5_human | 291 | 6.30x30 | TM6 | E => GlyfsTer26 | frameshift | 2.558e-05 | 3 | 117258 | 0 | None | None | SodiumPocket MicroSwitch |
drd5_human | 312 | 6.51x51 | TM6 | F => LeufsTer5 | frameshift | 8.401e-06 | 1 | 119036 | 0 | None | None | LB (hydrophobic, Van der Waals) |
drd5_human | 335 | ECL3 | C => Ter | stop gained | 0.001748 | 212 | 121312 | 1 | None | None | ||
drd5_human | 338 | 7.32x31 | TM7 | E => AspfsTer13 | frameshift | 2.473e-05 | 3 | 121334 | 0 | None | None | |
drd5_human | 366 | 8.51x51 | H8 | Q => ArgfsTer22 | frameshift | 1.648e-05 | 2 | 121394 | 0 | None | None | GP (contact) |
drd5_human | 366 | 8.51x51 | H8 | Q => Ter | stop gained | 1.648e-05 | 2 | 121392 | 0 | None | None | GP (contact) |
drd5_human | 371 | 8.56x56 | H8 | Q => Ter | stop gained | 8.239e-06 | 1 | 121380 | 0 | None | None | |
drd5_human | 375 | C-term | C => Ter | stop gained | 4.943e-05 | 6 | 121382 | 0 | None | None | ||
drd5_human | 396 | C-term | Y => Ter | stop gained | 8.238e-06 | 1 | 121384 | 0 | None | None | ||
drd5_human | 413 | C-term | M => AspfsTer35 | frameshift | 8.238e-06 | 1 | 121394 | 0 | None | None | ||
drd5_human | 429 | C-term | E => Ter | stop gained | 1.648e-05 | 2 | 121386 | 0 | None | None | ||
drd5_human | 441 | C-term | Y => Ter | stop gained | 8.243e-06 | 1 | 121320 | 0 | None | None | ||
drd5_human | 455 | C-term | W => Ter | stop gained | 8.262e-06 | 1 | 121040 | 0 | None | None | ||
drd5_human | 462 | C-term | E => GlyfsTer4 | frameshift | 8.32e-06 | 1 | 120196 | 0 | None | None | ||
drd5_human | 477 | C-term | H => IlefsTer5 | frameshift | 1.771e-05 | 2 | 112920 | 0 | None | None | ||
drd5_human | 2 | N-term | L => P | missense | 0.0001198 | 1 | 8348 | 0 | nan | 0.998 | ||
drd5_human | 4 | N-term | P => R | missense | 9.737e-05 | 1 | 10270 | 0 | nan | 0.041 | ||
drd5_human | 11 | N-term | Y => H | missense | 5.399e-05 | 1 | 18522 | 0 | nan | 0.0 | ||
drd5_human | 15 | N-term | F => L | missense | 4.137e-05 | 1 | 24172 | 0 | nan | 0.001 | ||
drd5_human | 16 | N-term | A => P | missense | 7.649e-05 | 2 | 26148 | 0 | nan | 0.001 | ||
drd5_human | 16 | N-term | A => T | missense | 3.824e-05 | 1 | 26148 | 0 | nan | 0.011 | ||
drd5_human | 17 | N-term | L => V | missense | 3.59e-05 | 1 | 27854 | 0 | nan | 0.0 | ||
drd5_human | 18 | N-term | Y => D | missense | 6.893e-05 | 2 | 29014 | 0 | nan | 0.002 | ||
drd5_human | 21 | N-term | L => Q | missense | 6.005e-05 | 2 | 33306 | 0 | nan | 0.154 | ||
drd5_human | 23 | N-term | Q => H | missense | 5.442e-05 | 2 | 36752 | 0 | nan | 0.188 | ||
drd5_human | 24 | N-term | G => R | missense | 2.685e-05 | 1 | 37240 | 0 | nan | 0.0 | ||
drd5_human | 25 | N-term | N => S | missense | 2.581e-05 | 1 | 38750 | 0 | nan | 0.004 | ||
drd5_human | 27 | N-term | V => L | missense | 9.833e-05 | 4 | 40678 | 0 | 1.0 | 0.001 | ||
drd5_human | 28 | N-term | G => E | missense | 9.717e-05 | 4 | 41166 | 0 | nan | 0.028 | ||
drd5_human | 32 | N-term | G => E | missense | 2.299e-05 | 1 | 43506 | 0 | 0.53 | 0.028 | ||
drd5_human | 33 | N-term | A => T | missense | 2.283e-05 | 1 | 43808 | 0 | 0.55 | 0.003 | ||
drd5_human | 33 | N-term | A => E | missense | 2.375e-05 | 1 | 42100 | 0 | 1.0 | 0.003 | ||
drd5_human | 34 | N-term | P => Q | missense | 2.193e-05 | 1 | 45600 | 0 | 0.08 | 0.001 | ||
drd5_human | 34 | N-term | P => R | missense | 2.193e-05 | 1 | 45600 | 0 | 0.05 | 0.028 | ||
drd5_human | 37 | N-term | G => R | missense | 1.985e-05 | 1 | 50366 | 0 | 0.13 | 0.999 | ||
drd5_human | 41 | 1.33x33 | TM1 | V => A | missense | 0.0001727 | 10 | 57914 | 0 | 0.31 | 0.015 | |
drd5_human | 46 | 1.38x38 | TM1 | L => P | missense | 1.26e-05 | 1 | 79334 | 0 | 0.0 | 0.962 | |
drd5_human | 47 | 1.39x39 | TM1 | L => V | missense | 0.00011 | 9 | 81834 | 0 | 0.02 | 0.997 | |
drd5_human | 52 | 1.44x44 | TM1 | I => T | missense | 1.031e-05 | 1 | 96982 | 0 | 0.0 | 0.034 | |
drd5_human | 53 | 1.45x45 | TM1 | W => R | missense | 1.021e-05 | 1 | 97956 | 0 | 0.22 | 0.668 | |
drd5_human | 54 | 1.46x46 | TM1 | T => N | missense | 9.955e-06 | 1 | 100456 | 0 | 0.0 | 0.999 | |
drd5_human | 57 | 1.49x49 | TM1 | G => D | missense | 2.815e-05 | 3 | 106570 | 0 | 0.0 | 1.0 | |
drd5_human | 58 | 1.50x50 | TM1 | N => K | missense | 9.234e-06 | 1 | 108292 | 0 | 0.0 | 0.985 | |
drd5_human | 61 | 1.53x53 | TM1 | V => M | missense | 0.0001178 | 13 | 110388 | 0 | 0.0 | 0.99 | |
drd5_human | 62 | 1.54x54 | TM1 | C => S | missense | 0.0001169 | 13 | 111192 | 0 | 0.0 | 0.812 | |
drd5_human | 63 | 1.55x55 | TM1 | A => V | missense | 1.765e-05 | 2 | 113310 | 0 | 0.43 | 0.03 | |
drd5_human | 68 | 1.60x60 | TM1 | S => R | missense | 1.712e-05 | 2 | 116806 | 0 | 0.02 | 0.864 | |
drd5_human | 69 | 12.48x48 | ICL1 | R => G | missense | 8.548e-06 | 1 | 116984 | 0 | 0.01 | 0.964 | |
drd5_human | 72 | 12.51x51 | ICL1 | R => C | missense | 8.456e-06 | 1 | 118258 | 0 | 0.0 | 0.998 | |
drd5_human | 75 | 2.38x38 | TM2 | M => V | missense | 1.671e-05 | 2 | 119678 | 0 | 1.0 | 0.016 | |
drd5_human | 75 | 2.38x38 | TM2 | M => T | missense | 0.00111 | 133 | 119798 | 1 | 0.07 | 0.02 | |
drd5_human | 76 | 2.39x39 | TM2 | T => I | missense | 8.33e-06 | 1 | 120044 | 0 | 0.0 | 0.998 | |
drd5_human | 78 | 2.41x41 | TM2 | V => I | missense | 1.662e-05 | 2 | 120326 | 0 | 0.63 | 0.021 | |
drd5_human | 78 | 2.41x41 | TM2 | V => G | missense | 9.968e-05 | 12 | 120386 | 0 | 0.04 | 0.493 | |
drd5_human | 83 | 2.46x46 | TM2 | L => P | missense | 3.311e-05 | 4 | 120818 | 0 | 0.0 | 1.0 | |
drd5_human | 85 | 2.48x48 | TM2 | V => A | missense | 1.651e-05 | 2 | 121158 | 0 | 0.0 | 0.863 | |
drd5_human | 88 | 2.51x51 | TM2 | L => F | missense | 0.004521 | 548 | 121200 | 1 | 0.0 | 1.0 | |
drd5_human | 89 | 2.52x52 | TM2 | F => S | missense | 1.65e-05 | 2 | 121214 | 0 | 0.05 | 0.857 | |
drd5_human | 91 | 2.54x54 | TM2 | A => P | missense | 3.3e-05 | 4 | 121214 | 0 | 0.0 | 1.0 | |
drd5_human | 91 | 2.54x54 | TM2 | A => E | missense | 8.25e-06 | 1 | 121218 | 0 | 0.0 | 1.0 | |
drd5_human | 101 | 2.64x63 | TM2 | A => T | missense | 1.649e-05 | 2 | 121254 | 0 | 0.67 | 0.08 | |
drd5_human | 103 | 2.66x65 | TM2 | V => M | missense | 8.246e-06 | 1 | 121266 | 0 | 0.0 | 0.997 | |
drd5_human | 106 | 23.49x49 | ECL1 | Y => H | missense | 0.0001731 | 21 | 121284 | 0 | 0.16 | 0.071 | |
drd5_human | 108 | 23.51x51 | ECL1 | P => T | missense | 3.299e-05 | 4 | 121260 | 0 | 0.05 | 0.904 | |
drd5_human | 108 | 23.51x51 | ECL1 | P => L | missense | 7.421e-05 | 9 | 121272 | 0 | 0.42 | 0.107 | |
drd5_human | 110 | 3.22x22 | TM3 | G => E | missense | 7.431e-05 | 9 | 121118 | 0 | 0.01 | 0.873 | |
drd5_human | 111 | 3.23x23 | TM3 | A => V | missense | 4.124e-05 | 5 | 121254 | 0 | 0.03 | 0.223 | |
drd5_human | 111 | 3.23x23 | TM3 | A => E | missense | 8.247e-06 | 1 | 121254 | 0 | 0.13 | 0.564 | |
drd5_human | 113 | 3.25x25 | TM3 | C => S | missense | 8.247e-06 | 1 | 121258 | 0 | 0.0 | 0.992 | |
drd5_human | 114 | 3.26x26 | TM3 | D => N | missense | 8.247e-06 | 1 | 121258 | 0 | 0.56 | 0.055 | |
drd5_human | 115 | 3.27x27 | TM3 | V => I | missense | 8.247e-06 | 1 | 121254 | 0 | 0.64 | 0.05 | |
drd5_human | 115 | 3.27x27 | TM3 | V => F | missense | 2.474e-05 | 3 | 121254 | 0 | 0.0 | 0.915 | |
drd5_human | 123 | 3.35x35 | TM3 | C => Y | missense | 3.3e-05 | 4 | 121230 | 0 | 0.0 | 1.0 | |
drd5_human | 125 | 3.37x37 | TM3 | T => A | missense | 8.249e-06 | 1 | 121224 | 0 | 0.0 | 1.0 | LB (polar (hydrogen bond)) |
drd5_human | 126 | 3.38x38 | TM3 | A => V | missense | 8.25e-06 | 1 | 121214 | 0 | 0.0 | 1.0 | |
drd5_human | 127 | 3.39x39 | TM3 | S => F | missense | 4.125e-05 | 5 | 121200 | 0 | 0.0 | 1.0 | |
drd5_human | 131 | 3.43x43 | TM3 | L => P | missense | 8.252e-06 | 1 | 121190 | 0 | 0.0 | 1.0 | |
drd5_human | 133 | 3.45x45 | TM3 | V => I | missense | 8.259e-06 | 1 | 121082 | 0 | 0.83 | 0.037 | |
drd5_human | 135 | 3.47x47 | TM3 | S => T | missense | 8.255e-06 | 1 | 121146 | 0 | 0.0 | 1.0 | |
drd5_human | 138 | 3.50x50 | TM3 | R => C | missense | 2.477e-05 | 3 | 121104 | 0 | 0.01 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
drd5_human | 138 | 3.50x50 | TM3 | R => L | missense | 2.477e-05 | 3 | 121108 | 0 | 0.0 | 0.999 | SodiumPocket MicroSwitch GP (contact) |
drd5_human | 141 | 3.53x53 | TM3 | A => S | missense | 8.26e-06 | 1 | 121072 | 0 | 0.0 | 0.999 | GP (contact) |
drd5_human | 149 | 34.54x54 | ICL2 | K => E | missense | 4.961e-05 | 6 | 120952 | 0 | 1.0 | 0.001 | GP (contact) |
drd5_human | 150 | 34.55x55 | ICL2 | R => C | missense | 8.266e-06 | 1 | 120972 | 0 | 0.01 | 0.262 | GP (contact) |
drd5_human | 152 | 34.57x57 | ICL2 | M => I | missense | 8.268e-06 | 1 | 120942 | 0 | 0.0 | 0.999 | GP (contact) |
drd5_human | 155 | 4.40x40 | TM4 | R => H | missense | 8.275e-06 | 1 | 120840 | 0 | 0.06 | 0.126 | |
drd5_human | 157 | 4.42x42 | TM4 | A => D | missense | 8.274e-06 | 1 | 120858 | 0 | 0.0 | 0.997 | |
drd5_human | 158 | 4.43x43 | TM4 | L => F | missense | 1.655e-05 | 2 | 120822 | 0 | 1.0 | 0.03 | |
drd5_human | 162 | 4.47x47 | TM4 | G => R | missense | 8.282e-06 | 1 | 120746 | 0 | 0.0 | 0.762 | |
drd5_human | 170 | 4.55x55 | TM4 | L => P | missense | 8.305e-06 | 1 | 120406 | 0 | 0.0 | 0.995 | |
drd5_human | 171 | 4.56x56 | TM4 | I => V | missense | 8.304e-06 | 1 | 120418 | 0 | 0.06 | 0.341 | |
drd5_human | 173 | 4.58x58 | TM4 | F => L | missense | 1.665e-05 | 2 | 120136 | 0 | 0.04 | 0.914 | |
drd5_human | 175 | 4.60x60 | TM4 | P => L | missense | 2.5e-05 | 3 | 119978 | 0 | 0.0 | 1.0 | |
drd5_human | 176 | 4.61x61 | TM4 | V => A | missense | 7.501e-05 | 9 | 119992 | 0 | 0.0 | 0.999 | |
drd5_human | 177 | 4.62x62 | TM4 | Q => H | missense | 8.339e-06 | 1 | 119920 | 0 | 0.08 | 0.33 | |
drd5_human | 179 | 4.64x64 | TM4 | N => S | missense | 1.669e-05 | 2 | 119840 | 0 | 0.17 | 0.057 | |
drd5_human | 179 | 4.64x64 | TM4 | N => T | missense | 8.344e-06 | 1 | 119840 | 0 | 0.01 | 0.392 | |
drd5_human | 183 | ECL2 | D => H | missense | 8.358e-06 | 1 | 119640 | 0 | 0.12 | 0.806 | ||
drd5_human | 184 | ECL2 | Q => E | missense | 8.365e-06 | 1 | 119546 | 0 | 0.87 | 0.002 | ||
drd5_human | 184 | ECL2 | Q => P | missense | 8.362e-06 | 1 | 119584 | 0 | 0.23 | 0.18 | ||
drd5_human | 185 | ECL2 | A => V | missense | 8.364e-06 | 1 | 119558 | 0 | 0.31 | 0.014 | ||
drd5_human | 188 | ECL2 | W => L | missense | 1.672e-05 | 2 | 119598 | 0 | 0.65 | 0.003 | ||
drd5_human | 190 | ECL2 | G => W | missense | 1.671e-05 | 2 | 119678 | 0 | 0.0 | 0.917 | ||
drd5_human | 190 | ECL2 | G => V | missense | 8.355e-06 | 1 | 119694 | 0 | 0.03 | 0.243 | ||
drd5_human | 191 | ECL2 | L => P | missense | 8.353e-06 | 1 | 119724 | 0 | 0.25 | 0.0 | ||
drd5_human | 192 | ECL2 | D => Y | missense | 8.35e-06 | 1 | 119754 | 0 | 0.02 | 0.328 | ||
drd5_human | 192 | ECL2 | D => G | missense | 1.67e-05 | 2 | 119758 | 0 | 0.3 | 0.003 | ||
drd5_human | 195 | ECL2 | N => K | missense | 8.342e-06 | 1 | 119872 | 0 | 0.39 | 0.05 | ||
drd5_human | 196 | ECL2 | N => H | missense | 8.34e-06 | 1 | 119904 | 0 | 0.14 | 0.004 | ||
drd5_human | 197 | ECL2 | L => V | missense | 1.668e-05 | 2 | 119904 | 0 | 0.49 | 0.257 | ||
drd5_human | 198 | ECL2 | A => D | missense | 0.0002084 | 25 | 119942 | 0 | 0.14 | 0.016 | ||
drd5_human | 198 | ECL2 | A => V | missense | 1.667e-05 | 2 | 119942 | 0 | 0.14 | 0.016 | ||
drd5_human | 200 | ECL2 | W => R | missense | 8.336e-06 | 1 | 119966 | 0 | 0.35 | 0.0 | ||
drd5_human | 201 | ECL2 | T => A | missense | 8.331e-06 | 1 | 120038 | 0 | 0.1 | 0.869 | ||
drd5_human | 205 | ECL2 | E => D | missense | 8.313e-06 | 1 | 120300 | 0 | 0.13 | 0.006 | ||
drd5_human | 211 | ECL2 | D => N | missense | 0.0005554 | 67 | 120628 | 0 | 0.26 | 0.005 | ||
drd5_human | 215 | ECL2 | E => G | missense | 8.271e-06 | 1 | 120902 | 0 | 0.35 | 0.03 | ||
drd5_human | 219 | 45.52x52 | ECL2 | S => F | missense | 4.959e-05 | 6 | 120996 | 0 | 0.1 | 0.997 | LB (polar (hydrogen bond), polar (hydrogen bond with backbone)) |
drd5_human | 226 | 5.39x40 | TM5 | A => S | missense | 8.255e-06 | 1 | 121140 | 0 | 0.01 | 1.0 | |
drd5_human | 228 | 5.41x42 | TM5 | S => P | missense | 8.252e-06 | 1 | 121178 | 0 | 0.0 | 0.984 | |
drd5_human | 233 | 5.46x461 | TM5 | S => T | missense | 8.248e-06 | 1 | 121238 | 0 | 0.0 | 1.0 | LB (polar (hydrogen bond)) |
drd5_human | 234 | 5.47x47 | TM5 | F => Y | missense | 1.65e-05 | 2 | 121234 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
drd5_human | 236 | 5.49x49 | TM5 | I => F | missense | 1.65e-05 | 2 | 121228 | 0 | 0.0 | 0.973 | |
drd5_human | 238 | 5.51x51 | TM5 | V => G | missense | 4.126e-05 | 5 | 121192 | 0 | 0.0 | 0.993 | |
drd5_human | 239 | 5.52x52 | TM5 | A => V | missense | 8.253e-06 | 1 | 121174 | 0 | 0.15 | 0.042 | |
drd5_human | 241 | 5.54x54 | TM5 | M => I | missense | 4.954e-05 | 6 | 121122 | 0 | 0.06 | 0.999 | |
drd5_human | 241 | 5.54x54 | TM5 | M => I | missense | 6.605e-05 | 8 | 121122 | 0 | 0.06 | 0.999 | |
drd5_human | 242 | 5.55x55 | TM5 | I => V | missense | 0.0001239 | 15 | 121104 | 0 | 0.19 | 0.075 | |
drd5_human | 247 | 5.60x60 | TM5 | R => C | missense | 8.295e-06 | 1 | 120558 | 0 | 0.08 | 0.908 | |
drd5_human | 247 | 5.60x60 | TM5 | R => G | missense | 8.295e-06 | 1 | 120558 | 0 | 0.0 | 0.999 | |
drd5_human | 247 | 5.60x60 | TM5 | R => L | missense | 2.489e-05 | 3 | 120538 | 0 | 0.01 | 0.998 | |
drd5_human | 250 | 5.63x63 | TM5 | R => C | missense | 8.305e-06 | 1 | 120406 | 0 | 0.04 | 0.998 | |
drd5_human | 252 | 5.65x65 | TM5 | A => S | missense | 8.325e-06 | 1 | 120116 | 0 | 0.0 | 0.998 | GP (contact) |
drd5_human | 257 | 5.70x70 | TM5 | R => H | missense | 1.674e-05 | 2 | 119494 | 0 | 0.01 | 0.351 | |
drd5_human | 258 | 5.71x71 | TM5 | R => K | missense | 1.675e-05 | 2 | 119438 | 0 | 0.04 | 0.999 | GP (contact) |
drd5_human | 258 | 5.71x71 | TM5 | R => S | missense | 8.376e-06 | 1 | 119392 | 0 | 0.03 | 1.0 | GP (contact) |
drd5_human | 259 | 5.72x72 | TM5 | I => V | missense | 0.0001927 | 23 | 119342 | 0 | 0.01 | 0.889 | GP (contact) |
drd5_human | 263 | 5.76x76 | TM5 | E => G | missense | 1.689e-05 | 2 | 118448 | 0 | 0.04 | 1.0 | |
drd5_human | 266 | 5.79x79 | TM5 | A => S | missense | 8.476e-06 | 1 | 117978 | 0 | 0.02 | 0.767 | |
drd5_human | 267 | 5.80x80 | TM5 | E => Q | missense | 8.471e-06 | 1 | 118044 | 0 | 0.16 | 0.159 | |
drd5_human | 268 | 5.81x81 | TM5 | H => Q | missense | 0.0003736 | 44 | 117760 | 0 | 0.13 | 0.303 | |
drd5_human | 268 | 5.81x81 | TM5 | H => Q | missense | 2.548e-05 | 3 | 117760 | 0 | 0.13 | 0.303 | |
drd5_human | 269 | 5.82x82 | TM5 | A => T | missense | 1.702e-05 | 2 | 117528 | 0 | 0.04 | 0.532 | |
drd5_human | 269 | 5.82x82 | TM5 | A => V | missense | 0.000179 | 21 | 117314 | 0 | 0.05 | 0.127 | |
drd5_human | 273 | 5.86x86 | TM5 | R => G | missense | 8.575e-06 | 1 | 116624 | 0 | 0.07 | 0.089 | |
drd5_human | 273 | 5.86x86 | TM5 | R => W | missense | 6.002e-05 | 7 | 116624 | 0 | 0.02 | 0.954 | |
drd5_human | 273 | 5.86x86 | TM5 | R => Q | missense | 2.571e-05 | 3 | 116682 | 0 | 0.4 | 0.055 | |
drd5_human | 275 | ICL3 | S => T | missense | 1.741e-05 | 2 | 114892 | 0 | 0.47 | 0.139 | ||
drd5_human | 275 | ICL3 | S => R | missense | 8.824e-05 | 10 | 113326 | 0 | 0.6 | 0.004 | ||
drd5_human | 279 | ICL3 | A => V | missense | 8.711e-06 | 1 | 114796 | 0 | 0.23 | 0.024 | ||
drd5_human | 285 | 6.24x24 | TM6 | R => C | missense | 8.564e-06 | 1 | 116774 | 0 | 0.0 | 0.954 | |
drd5_human | 285 | 6.24x24 | TM6 | R => S | missense | 8.564e-06 | 1 | 116774 | 0 | 0.0 | 0.664 | |
drd5_human | 286 | 6.25x25 | TM6 | A => T | missense | 4.278e-05 | 5 | 116866 | 0 | 0.78 | 0.004 | GP (contact) |
drd5_human | 289 | 6.28x28 | TM6 | K => R | missense | 2.56e-05 | 3 | 117196 | 0 | 0.67 | 0.052 | GP (contact) |
drd5_human | 290 | 6.29x29 | TM6 | K => T | missense | 8.528e-06 | 1 | 117258 | 0 | 0.0 | 0.991 | GP (contact) |
drd5_human | 292 | 6.31x31 | TM6 | T => S | missense | 6.813e-05 | 8 | 117414 | 0 | 0.01 | 0.936 | |
drd5_human | 293 | 6.32x32 | TM6 | K => E | missense | 1.703e-05 | 2 | 117440 | 0 | 0.03 | 0.558 | GP (contact) |
drd5_human | 294 | 6.33x33 | TM6 | V => I | missense | 8.507e-06 | 1 | 117546 | 0 | 0.03 | 0.999 | GP (contact) |
drd5_human | 297 | 6.36x36 | TM6 | T => S | missense | 8.429e-06 | 1 | 118640 | 0 | 0.0 | 1.0 | GP (contact) |
drd5_human | 299 | 6.38x38 | TM6 | S => P | missense | 8.431e-06 | 1 | 118612 | 0 | 0.0 | 0.99 | |
drd5_human | 302 | 6.41x41 | TM6 | M => T | missense | 8.423e-05 | 10 | 118728 | 0 | 0.0 | 0.904 | |
drd5_human | 304 | 6.43x43 | TM6 | V => F | missense | 8.422e-06 | 1 | 118734 | 0 | 0.0 | 0.988 | |
drd5_human | 306 | 6.45x45 | TM6 | V => L | missense | 8.418e-06 | 1 | 118800 | 0 | 0.04 | 1.0 | |
drd5_human | 312 | 6.51x51 | TM6 | F => L | missense | 1.679e-05 | 2 | 119124 | 0 | 0.01 | 1.0 | LB (hydrophobic, Van der Waals) |
drd5_human | 314 | 6.53x53 | TM6 | I => N | missense | 8.387e-06 | 1 | 119234 | 0 | 0.0 | 0.88 | |
drd5_human | 314 | 6.53x53 | TM6 | I => T | missense | 1.677e-05 | 2 | 119234 | 0 | 0.0 | 0.426 | |
drd5_human | 315 | 6.54x54 | TM6 | L => P | missense | 5.867e-05 | 7 | 119304 | 0 | 0.0 | 0.999 | |
drd5_human | 319 | 6.58x58 | TM6 | V => I | missense | 8.349e-06 | 1 | 119770 | 0 | 0.07 | 0.856 | |
drd5_human | 320 | 6.59x59 | TM6 | P => R | missense | 8.341e-06 | 1 | 119896 | 0 | 0.0 | 1.0 | |
drd5_human | 322 | 6.61x61 | TM6 | C => F | missense | 1.665e-05 | 2 | 120128 | 0 | 0.01 | 1.0 | |
drd5_human | 323 | ECL3 | S => N | missense | 4.159e-05 | 5 | 120214 | 0 | 0.36 | 0.008 | ||
drd5_human | 325 | ECL3 | H => Y | missense | 1.662e-05 | 2 | 120338 | 0 | 0.04 | 0.063 | ||
drd5_human | 328 | ECL3 | G => D | missense | 8.248e-06 | 1 | 121240 | 0 | 0.61 | 0.006 | ||
drd5_human | 330 | ECL3 | P => Q | missense | 0.01211 | 1468 | 121242 | 33 | 0.64 | 0.016 | ||
drd5_human | 330 | ECL3 | P => L | missense | 4.949e-05 | 6 | 121242 | 0 | 0.3 | 0.002 | ||
drd5_human | 331 | ECL3 | A => T | missense | 8.246e-06 | 1 | 121272 | 0 | 0.15 | 0.033 | ||
drd5_human | 336 | ECL3 | V => I | missense | 1.649e-05 | 2 | 121314 | 0 | 0.25 | 0.981 | ||
drd5_human | 337 | 7.31x30 | TM7 | S => C | missense | 1.648e-05 | 2 | 121332 | 0 | 0.0 | 0.988 | |
drd5_human | 337 | 7.31x30 | TM7 | S => G | missense | 8.242e-06 | 1 | 121332 | 0 | 0.14 | 0.248 | |
drd5_human | 337 | 7.31x30 | TM7 | S => T | missense | 8.242e-06 | 1 | 121332 | 0 | 0.01 | 0.633 | |
drd5_human | 338 | 7.32x31 | TM7 | E => D | missense | 8.241e-06 | 1 | 121340 | 0 | 0.41 | 0.042 | |
drd5_human | 339 | 7.33x32 | TM7 | T => N | missense | 8.241e-06 | 1 | 121346 | 0 | 0.01 | 0.987 | |
drd5_human | 345 | 7.39x38 | TM7 | V => I | missense | 5.767e-05 | 7 | 121374 | 0 | 0.03 | 0.573 | LB (polar (hydrogen bond), polar (hydrogen bond with backbone)) |
drd5_human | 346 | 7.40x39 | TM7 | W => C | missense | 8.239e-06 | 1 | 121374 | 0 | 0.0 | 0.942 | |
drd5_human | 347 | 7.41x40 | TM7 | F => I | missense | 8.239e-06 | 1 | 121376 | 0 | 0.07 | 0.603 | |
drd5_human | 347 | 7.41x40 | TM7 | F => L | missense | 8.238e-06 | 1 | 121382 | 0 | 0.3 | 0.052 | |
drd5_human | 348 | 7.42x41 | TM7 | G => S | missense | 1.648e-05 | 2 | 121382 | 0 | 0.0 | 0.996 | LB (Van der Waals) |
drd5_human | 348 | 7.42x41 | TM7 | G => R | missense | 8.238e-06 | 1 | 121382 | 0 | 0.01 | 0.999 | LB (Van der Waals) |
drd5_human | 350 | 7.44x43 | TM7 | A => P | missense | 8.238e-06 | 1 | 121384 | 0 | 0.0 | 0.983 | SodiumPocket MicroSwitch |
drd5_human | 352 | 7.46x46 | TM7 | S => P | missense | 6.59e-05 | 8 | 121390 | 0 | 0.0 | 1.0 | |
drd5_human | 352 | 7.46x46 | TM7 | S => F | missense | 8.238e-06 | 1 | 121392 | 0 | 0.0 | 1.0 | |
drd5_human | 354 | 7.48x48 | TM7 | L => V | missense | 8.238e-06 | 1 | 121392 | 0 | 0.1 | 1.0 | |
drd5_human | 357 | 7.51x51 | TM7 | V => L | missense | 2.471e-05 | 3 | 121392 | 0 | 0.05 | 0.281 | |
drd5_human | 357 | 7.51x51 | TM7 | V => F | missense | 8.238e-06 | 1 | 121392 | 0 | 0.05 | 0.866 | |
drd5_human | 358 | 7.52x52 | TM7 | I => T | missense | 8.238e-06 | 1 | 121388 | 0 | 0.0 | 0.978 | |
drd5_human | 359 | 7.53x53 | TM7 | Y => S | missense | 1.648e-05 | 2 | 121394 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
drd5_human | 360 | 7.54x54 | TM7 | A => T | missense | 8.238e-06 | 1 | 121392 | 0 | 0.01 | 1.0 | |
drd5_human | 361 | 7.55x55 | TM7 | F => V | missense | 4.943e-05 | 6 | 121394 | 0 | 0.0 | 0.839 | GP (contact) |
drd5_human | 362 | 8.47x47 | H8 | N => K | missense | 1.648e-05 | 2 | 121396 | 0 | 0.0 | 0.973 | GP (contact) |
drd5_human | 364 | 8.49x49 | H8 | D => G | missense | 6.59e-05 | 8 | 121398 | 0 | 0.0 | 0.977 | GP (contact) |
drd5_human | 365 | 8.50x50 | H8 | F => C | missense | 8.238e-06 | 1 | 121392 | 0 | 0.0 | 1.0 | |
drd5_human | 366 | 8.51x51 | H8 | Q => R | missense | 0.0001565 | 19 | 121390 | 0 | 1.0 | 0.0 | GP (contact) |
drd5_human | 374 | 8.59x59 | H8 | G => R | missense | 3.295e-05 | 4 | 121382 | 0 | 0.04 | 0.555 | |
drd5_human | 374 | 8.59x59 | H8 | G => R | missense | 8.238e-06 | 1 | 121382 | 0 | 0.04 | 0.555 | |
drd5_human | 375 | C-term | C => Y | missense | 8.255e-06 | 1 | 121146 | 0 | 0.0 | 0.885 | ||
drd5_human | 381 | C-term | R => C | missense | 8.24e-06 | 1 | 121366 | 0 | 0.03 | 0.772 | ||
drd5_human | 382 | C-term | T => M | missense | 8.239e-06 | 1 | 121378 | 0 | 0.0 | 0.886 | ||
drd5_human | 387 | C-term | V => E | missense | 8.239e-06 | 1 | 121378 | 0 | 0.0 | 0.846 | ||
drd5_human | 388 | C-term | N => Y | missense | 8.239e-06 | 1 | 121380 | 0 | 0.0 | 0.903 | ||
drd5_human | 394 | C-term | I => F | missense | 1.648e-05 | 2 | 121386 | 0 | 0.04 | 0.128 | ||
drd5_human | 394 | C-term | I => T | missense | 1.648e-05 | 2 | 121386 | 0 | 0.05 | 0.06 | ||
drd5_human | 395 | C-term | S => F | missense | 0.0002389 | 29 | 121382 | 0 | 0.01 | 0.999 | ||
drd5_human | 397 | C-term | N => H | missense | 8.238e-06 | 1 | 121384 | 0 | 1.0 | 0.005 | ||
drd5_human | 399 | C-term | D => Y | missense | 8.238e-06 | 1 | 121386 | 0 | 0.0 | 0.949 | ||
drd5_human | 401 | C-term | V => I | missense | 8.239e-06 | 1 | 121380 | 0 | 0.19 | 0.002 | ||
drd5_human | 407 | C-term | A => T | missense | 8.238e-06 | 1 | 121394 | 0 | 0.21 | 0.003 | ||
drd5_human | 407 | C-term | A => V | missense | 8.238e-06 | 1 | 121396 | 0 | 0.66 | 0.002 | ||
drd5_human | 413 | C-term | M => V | missense | 1.648e-05 | 2 | 121392 | 0 | 0.63 | 0.001 | ||
drd5_human | 413 | C-term | M => L | missense | 8.238e-06 | 1 | 121392 | 0 | 1.0 | 0.011 | ||
drd5_human | 413 | C-term | M => R | missense | 8.238e-06 | 1 | 121394 | 0 | 0.21 | 0.004 | ||
drd5_human | 418 | C-term | V => I | missense | 0.0001318 | 16 | 121396 | 1 | 0.3 | 0.06 | ||
drd5_human | 418 | C-term | V => F | missense | 8.238e-06 | 1 | 121396 | 0 | 0.01 | 0.897 | ||
drd5_human | 423 | C-term | R => Q | missense | 2.471e-05 | 3 | 121386 | 0 | 0.57 | 0.053 | ||
drd5_human | 427 | C-term | N => K | missense | 8.238e-06 | 1 | 121388 | 0 | 1.0 | 0.0 | ||
drd5_human | 428 | C-term | D => N | missense | 8.238e-06 | 1 | 121388 | 0 | 0.38 | 0.004 | ||
drd5_human | 433 | C-term | P => R | missense | 8.239e-06 | 1 | 121378 | 0 | 0.12 | 0.005 | ||
drd5_human | 438 | C-term | F => S | missense | 6.592e-05 | 8 | 121356 | 0 | 1.0 | 0.0 | ||
drd5_human | 438 | C-term | F => L | missense | 8.24e-06 | 1 | 121354 | 0 | 0.17 | 0.0 | ||
drd5_human | 446 | C-term | D => G | missense | 5.773e-05 | 7 | 121258 | 0 | 0.4 | 0.002 | ||
drd5_human | 447 | C-term | G => S | missense | 4.124e-05 | 5 | 121250 | 0 | 0.85 | 0.101 | ||
drd5_human | 453 | C-term | S => T | missense | 8.255e-06 | 1 | 121132 | 0 | 0.04 | 0.254 | ||
drd5_human | 453 | C-term | S => C | missense | 0.0001321 | 16 | 121126 | 1 | 0.01 | 0.765 | ||
drd5_human | 460 | C-term | E => D | missense | 8.304e-06 | 1 | 120424 | 0 | 0.3 | 0.032 | ||
drd5_human | 461 | C-term | G => R | missense | 3.323e-05 | 4 | 120362 | 0 | 0.08 | 0.021 | ||
drd5_human | 461 | C-term | G => V | missense | 8.311e-06 | 1 | 120322 | 0 | 0.14 | 0.015 | ||
drd5_human | 462 | C-term | E => D | missense | 8.344e-06 | 1 | 119848 | 0 | 0.42 | 0.011 | ||
drd5_human | 465 | C-term | L => S | missense | 3.354e-05 | 4 | 119260 | 0 | 0.01 | 0.191 | ||
drd5_human | 469 | C-term | T => A | missense | 5.958e-05 | 7 | 117484 | 0 | 0.12 | 0.005 | ||
drd5_human | 475 | C-term | G => V | missense | 8.8e-06 | 1 | 113632 | 0 | 0.0 | 0.796 | ||
drd5_human | 477 | C-term | H => R | missense | 2.703e-05 | 3 | 111002 | 0 | 0.07 | 0.448 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue